Matibi Mission was cited by a white Full Gospel Church missionary called Mr Marurhie. Marurhie and his family came from South Africa and initially settled at Chesvingo area in Beitbridge. Upon his arrival in Zimbabwe, it is said Mr Marurhie could only speak Shangani(Probably acquired in South Africa) among all local Zimbabwean languages and hence his choice to settle in Shangani speaking communities in Zimbabwe. From Beitbridge the missionary moved further North of Beitbridge and settled closer to Neshuro area at a place commonly known today as Chesvingo in Mwenezi. It still remains a mystery today whether it's a coincidence of names or it’s the missionary himself who named the first two places he stayed CHESVINGO despite being in different Districts. The two places still exist with the same name, the former is now a Catholic Parish in Beitbridge and the later is a Primary School in Mwenezi. Around early 1950s Mr Marurhie arrived at Mushonganeburi hill where he set Matibi Mission. After arriving at Matibi, the missionary engaged a local Shangani resident called Mr Chauke who helped him and his family to set Full Gospel Church at Matibi as well as offering vocational courses to girl children from surrounding areas. As the vocational training centre continued to grow, the missionary opened a formal school where both boys and girls could enroll and the first head of the school was the late Mr Silaluke chosen from the Missionary’s Full Gospel Church. Probably due to increase in numbers around Matibi Mission (Some as full gospel Christians in church, others as girls in vocational training and most as school pupils) a clinic was built and the first nurse was the late Mrs Elesta Matshaba, who was a local resident.

The clinic was built where at present is occupied by a basketball court closer to Priests' offices. In 1962 Father Englin Exevia, who was a Catholic Priest at Berejena Mission in Chivi, was notified by Mr Ignatious Mukaro(a Catholic member who had relocated to Mwenezi from Gutu) about the death of Mr Marurhie and the intention of his living family members who were struggling to maintain the Mission and were ready to sell. On 08 December 1962 Matibi Mission was acquired by the Catholic Church and ceased to be a Full Gospel Church Mission but a Catholic Mission. In early 1970s Dominican Sisters arrived at Matibi Catholic Mission and these Sisters were Sister Lioba and Sister Myer. These two Sisters played significant roles in expanding then Matibi clinic, specifically by moving the clinic to a suitable site where expansion space was abundant (current position of Hospital).

The two mentioned sisters expanded the clinic to accommodate and serve more clients. In 1981 Fr Walter Nyatsanza also worked tirelessly using his pastoral work car to transfer patients (clinic had no Doctor) to hospitals as more clients with more challenging health problems flock to the fast expanding Clinic. Then came the famous Doctor Ashwandan in 1982 together with his Nigerian compatriot Dr Alkoyo. Dr Ashwandan managed to secure funds and Donors from Switzerland, commonly known as The Matibi Friends, for the Clinic who built necessary structures at the Clinic which helped the clinic to be given a hospital status in 1983. To date Matibi Friends provide unwavering support to the Hospital which enables the hospital to meet its goals and objectives as well as maintaining awesome infrastructure and plants at the hospital.